Zhongguo linchuang yanjiu (Jun 2024)
Predictive value of serum actinin-4, TFF1, and TGFBI for the prognosis of patients with primary hepatocellular carcinoma after transarterial chemoembolization
Abstract
Objective To investigate the predictive value of serum actinin-4, trefoil factor 1 (TFF1), and transforming growth factor-β-induced protein (TGFBI) for the prognosis of patients with primary hepatocellular carcinoma (PHC) after transarterial chemoembolization (TACE). Methods From January 2020 to May 2023, 312 patients with PHC who underwent TACE in Shijiazhuang People's Hospital were collected as the study subjects (PHC group), patients with PHC were separated into a group with good prognosis (n=252) and a group with poor prognosis (n=60) based on their postoperative conditions. And 312 subjects who underwent health examinations were selected as the control group. Serum levels of actinin-4, TFF1, and TGFBI were detected by ELISA. Logistic regression was applied to analyze the influencing factors of poor prognosis in patients with PHC after TACE. Receiver operating characteristic curve (ROC) was applied to analyze the predictive value of serum actinin-4, TFF1, and TGFBI for poor prognosis after TACE in patients with PHC. Results There was no significant difference in gender, age, Child-Pugh grade, and clinical stage between the group with good prognosis and the group with poor prognosis (P＞0.05), but there were statistically differences in tumor size and portal vein tumor thrombus (P＜0.05). Compared with control group, the serum levels of actinin-4 ［(45.67±10.23) pg/mL vs (28.25±6.96) pg/mL, t=24.868, P＜0.01］, TFF1 ［(5.04±1.53) ng/mL vs (2.32±0.64) ng/mL, t=28.969, P＜0.01］, TGFBI ［(19.16±4.36)ng/mL vs (10.25±2.43) ng/mL, t=31.530, P＜0.01］ were obviously higher in PHC group. Compared with the group with good prognosis, the serum levels of actinin-4, TFF1, and TGFBI in the group with poor prognosis were obviously increased (P＜0.01). The results of multivariate logistic regression analysis showed that tumor size, portal vein tumor thrombus, serum actinin-4, TFF1, and TGFBI were all influencing factors for poor prognosis of PHC patients after TACE (P＜0.05). ROC curve results showed that the combined prediction of serum actinin-4, TFF1, and TGFBI for poor prognosis after TACE in PHC patients had an AUC of 0.926, a sensitivity of 81.3%, and a specificity of 76.8%. Conclusion The serum levels of actinin-4, TFF1, and TGFBI in patients with poor prognosis after TACE for PHC are obviously increased, and the combined determination of the three has good predictive value for prognosis of patients.
Keywords
