Nature Communications (May 2019)
Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity
- Rhodora C. Calizo,
- Smiti Bhattacharya,
- J. G. Coen van Hasselt,
- Chengguo Wei,
- Jenny S. Wong,
- Robert J. Wiener,
- Xuhua Ge,
- Nicholas J. Wong,
- Jia-Jye Lee,
- Christina M. Cuttitta,
- Gomathi Jayaraman,
- Vivienne H. Au,
- William Janssen,
- Tong Liu,
- Hong Li,
- Fadi Salem,
- Edgar A. Jaimes,
- Barbara Murphy,
- Kirk N. Campbell,
- Evren U. Azeloglu
Affiliations
- Rhodora C. Calizo
- Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai
- Smiti Bhattacharya
- Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai
- J. G. Coen van Hasselt
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
- Chengguo Wei
- Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai
- Jenny S. Wong
- Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai
- Robert J. Wiener
- Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai
- Xuhua Ge
- Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai
- Nicholas J. Wong
- Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai
- Jia-Jye Lee
- Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai
- Christina M. Cuttitta
- Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai
- Gomathi Jayaraman
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
- Vivienne H. Au
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
- William Janssen
- Department of Neuroscience, Icahn School of Medicine at Mount Sinai
- Tong Liu
- Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers University–New Jersey Medical School
- Hong Li
- Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers University–New Jersey Medical School
- Fadi Salem
- Department of Pathology, Icahn School of Medicine at Mount Sinai
- Edgar A. Jaimes
- Renal Service, Memorial Sloan Kettering Cancer Center
- Barbara Murphy
- Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai
- Kirk N. Campbell
- Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai
- Evren U. Azeloglu
- Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai
- DOI
- https://doi.org/10.1038/s41467-019-09936-x
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Kinase inhibitors used in chemotherapy are known for their adverse effects on kidney physiology. Here, Calizo et al. show that dasatinib is associated with a higher risk of glomerular toxicity compared to other kinase inhibitors, due to deleterious effects on cytoskeletal biomechanics in podocytes.
