Tum/RacGAP functions as a switch activating the Pav/kinesin-6 motor

Li Tao; Barbara Fasulo; Brandt Warecki; William Sullivan

doi:10.1038/ncomms11182

Nature Communications (Apr 2016)

Tum/RacGAP functions as a switch activating the Pav/kinesin-6 motor

Li Tao,
Barbara Fasulo,
Brandt Warecki,
William Sullivan

Affiliations

Li Tao: Department of Biology, University of Hawaii at Hilo, 200 West Kawili Street, Hilo, Hawaii 96720, USA
Barbara Fasulo: Department of Molecular, Cellular and Developmental Biology, University of California
Brandt Warecki: Department of Molecular, Cellular and Developmental Biology, University of California
William Sullivan: Department of Molecular, Cellular and Developmental Biology, University of California

DOI: https://doi.org/10.1038/ncomms11182
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

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Centralspindlin consists of dimeric kinesin-6 and dimeric RacGAP, and is involved in the organization of anaphase midzone microtubules. Here, the authors show that the RacGAP is needed for motor activity at the plus-end of microtubules, but not for the bundling activity associated with kinesin-6.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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