Nature Communications (May 2019)
Caspase-1 initiates apoptosis in the absence of gasdermin D
- Kohsuke Tsuchiya,
- Shinsuke Nakajima,
- Shoko Hosojima,
- Dinh Thi Nguyen,
- Tsuyoshi Hattori,
- Thuong Manh Le,
- Osamu Hori,
- Mamunur Rashid Mahib,
- Yoshifumi Yamaguchi,
- Masayuki Miura,
- Takeshi Kinoshita,
- Hiroko Kushiyama,
- Mayumi Sakurai,
- Toshihiko Shiroishi,
- Takashi Suda
Affiliations
- Kohsuke Tsuchiya
- Division of Immunology and Molecular Biology, Cancer Research Institute, Kanazawa University
- Shinsuke Nakajima
- Division of Immunology and Molecular Biology, Cancer Research Institute, Kanazawa University
- Shoko Hosojima
- Division of Immunology and Molecular Biology, Cancer Research Institute, Kanazawa University
- Dinh Thi Nguyen
- Department of Neuroanatomy, Graduate School of Medical Sciences, Kanazawa University
- Tsuyoshi Hattori
- Department of Neuroanatomy, Graduate School of Medical Sciences, Kanazawa University
- Thuong Manh Le
- Department of Neuroanatomy, Graduate School of Medical Sciences, Kanazawa University
- Osamu Hori
- Department of Neuroanatomy, Graduate School of Medical Sciences, Kanazawa University
- Mamunur Rashid Mahib
- Division of Immunology and Molecular Biology, Cancer Research Institute, Kanazawa University
- Yoshifumi Yamaguchi
- Institute of Low Temperature Science, Hokkaido University
- Masayuki Miura
- Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
- Takeshi Kinoshita
- Division of Immunology and Molecular Biology, Cancer Research Institute, Kanazawa University
- Hiroko Kushiyama
- Division of Immunology and Molecular Biology, Cancer Research Institute, Kanazawa University
- Mayumi Sakurai
- Division of Immunology and Molecular Biology, Cancer Research Institute, Kanazawa University
- Toshihiko Shiroishi
- Mammalian Genetics Laboratory, Genetic Strains Research Center, National Institute of Genetics
- Takashi Suda
- Division of Immunology and Molecular Biology, Cancer Research Institute, Kanazawa University
- DOI
- https://doi.org/10.1038/s41467-019-09753-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 19
Abstract
In inflammasomes, caspase-1 activation leads to pyroptosis mediated by gasdermin D, but cells lacking gasdermin-D still initiate caspase-dependent cell death. Here, Tsuchiya et al. show that these cells undergo Bid- and caspase-3-dependent apoptosis.
