Roles of the calcified cartilage layer and its tissue engineering reconstruction in osteoarthritis treatment

Weiyang Wang; Weiyang Wang; Ruixi Ye; Ruixi Ye; Wenqing Xie; Wenqing Xie; Yueyao Zhang; Yueyao Zhang; Senbo An; Yusheng Li; Yusheng Li; Yang Zhou

doi:10.3389/fbioe.2022.911281

Frontiers in Bioengineering and Biotechnology (Aug 2022)

Roles of the calcified cartilage layer and its tissue engineering reconstruction in osteoarthritis treatment

Weiyang Wang,
Weiyang Wang,
Ruixi Ye,
Ruixi Ye,
Wenqing Xie,
Wenqing Xie,
Yueyao Zhang,
Yueyao Zhang,
Senbo An,
Yusheng Li,
Yusheng Li,
Yang Zhou

Affiliations

Weiyang Wang: Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China
Weiyang Wang: Xiangya School of Medicine, Central South University, Changsha, China
Ruixi Ye: Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China
Ruixi Ye: Xiangya School of Medicine, Central South University, Changsha, China
Wenqing Xie: Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China
Wenqing Xie: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Yueyao Zhang: Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China
Yueyao Zhang: Xiangya School of Medicine, Central South University, Changsha, China
Senbo An: Department of Orthopedics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China
Yusheng Li: Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China
Yusheng Li: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Yang Zhou: Department of Clinical Nursing, Xiangya Hospital, Central South University, Changsha, China

DOI: https://doi.org/10.3389/fbioe.2022.911281
Journal volume & issue: Vol. 10

Abstract

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Sandwiched between articular cartilage and subchondral bone, the calcified cartilage layer (CCL) takes on both biomechanical and biochemical functions in joint development and ordinary activities. The formation of CCL is not only unique in articular cartilage but can also be found in the chondro-osseous junction adjacent to the growth plate during adolescence. The formation of CCL is an active process under both cellular regulation and intercellular communication. Abnormal alterations of CCL can be indications of degenerative diseases including osteoarthritis. Owing to the limited self-repair capability of articular cartilage and core status of CCL in microenvironment maintenance, tissue engineering reconstruction of CCL in damaged cartilage can be of great significance. This review focuses on possible tissue engineering reconstruction methods targeting CCL for further OA treatment.

Published in Frontiers in Bioengineering and Biotechnology

ISSN: 2296-4185 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Technology: Chemical technology: Biotechnology
Website: http://www.frontiersin.org/bioengineering_and_biotechnology

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