Lipids in Health and Disease (Sep 2010)

Effect of hemodialysis and peritoneal dialysis on redox status in chronic renal failure patients: a comparative study

  • Mekki Khedidja,
  • Taleb Warda,
  • Bouzidi Nassima,
  • Kaddous Abbou,
  • Bouchenak Malika

DOI
https://doi.org/10.1186/1476-511X-9-93
Journal volume & issue
Vol. 9, no. 1
p. 93

Abstract

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Abstract Objective To investigate the effects of hemodialysis (HD) and periotoneal dialysis (PD) on oxidative stress in chronic renal failure patients (CRF). Methods 20 HD patients (M/F: 8/12, 36 ± 12 years) and 20 PD patients (M/F: 10/10, 40 ± 8 years) were compared with 20 end stage renal failure patients (CRF) (M/F: 4/16, 61 ± 13 years). Results Thiobarbituric acid reactive substances (TBARS) values were elevated in HD and decreased in PD compared to CRF (P 2 were decreased in HD and PD, compared to CRF (p 3 values between the three groups. Carbonyls were increased in HD (p Conclusion HD and PD aggravate oxidative stress generated by uremia. HD accentuates lipid and protein peroxidation, while PD aggravates protein oxidation. However, the activity of antioxidant enzymes was altered by both dialysis treatments.