Communications Biology (Jan 2021)

RNA editing enzyme APOBEC3A promotes pro-inflammatory M1 macrophage polarization

  • Emad Y. Alqassim,
  • Shraddha Sharma,
  • A. N. M. Nazmul H. Khan,
  • Tiffany R. Emmons,
  • Eduardo Cortes Gomez,
  • Abdulrahman Alahmari,
  • Kelly L. Singel,
  • Jaron Mark,
  • Bruce A. Davidson,
  • A. J. Robert McGray,
  • Qian Liu,
  • Brian D. Lichty,
  • Kirsten B. Moysich,
  • Jianmin Wang,
  • Kunle Odunsi,
  • Brahm H. Segal,
  • Bora E. Baysal

DOI
https://doi.org/10.1038/s42003-020-01620-x
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 11

Abstract

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Alqassim et al find that RNA editing, known to be induced by IFN-1 in macrophages by the enzyme APOBEC3A, is required for the transcriptional, pro-inflammatory and metabolic responses that drive M1 macrophage polarization. APOBEC3A-mediated editing is also induced by IFN-1 exposure in tumor-associated macrophages isolated from ovarian cancer-related ascites fluid, pointing to a wide role for APOBEC3A in macrophages.