Nature Communications (Aug 2021)

NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma

  • Seungyong Lee,
  • Charles Hwang,
  • Simone Marini,
  • Robert J. Tower,
  • Qizhi Qin,
  • Stefano Negri,
  • Chase A. Pagani,
  • Yuxiao Sun,
  • David M. Stepien,
  • Michael Sorkin,
  • Carrie A. Kubiak,
  • Noelle D. Visser,
  • Carolyn A. Meyers,
  • Yiyun Wang,
  • Husain A. Rasheed,
  • Jiajia Xu,
  • Sarah Miller,
  • Amanda K. Huber,
  • Liliana Minichiello,
  • Paul S. Cederna,
  • Stephen W. P. Kemp,
  • Thomas L. Clemens,
  • Aaron W. James,
  • Benjamin Levi

DOI
https://doi.org/10.1038/s41467-021-25143-z
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 20

Abstract

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Soft tissue trauma can result in aberrant osteochondral differentiation of local mesenchymal progenitor cells. Here the authors show that, in mice, soft tissue trauma results in NGF expression by perivascular cells, which leads to axonal invasion and drives abnormal osteochondral differentiation, and show that this process can be prevented by inhibition of NGF signaling.