Polycystins, ADPKD, and Cardiovascular Disease

Ivana Y. Kuo; Arlene B. Chapman

Kidney International Reports (Apr 2020)

Polycystins, ADPKD, and Cardiovascular Disease

Ivana Y. Kuo,
Arlene B. Chapman

Affiliations

Ivana Y. Kuo: Department of Cell and Molecular Physiology, Loyola University Chicago, Maywood, Illinois, USA; Correspondence: Ivana Y. Kuo, Department of Cell and Molecular Physiology, Loyola University Chicago, 2160 S. First Ave, Maywood, Illinois 60153, USA.
Arlene B. Chapman: Section of Nephrology, Department of Medicine, University of Chicago, Chicago, Illinois, USA; Arlene B. Chapman, Section of Nephrology, Department of Medicine, University of Chicago, 5841 S. Maryland Ave, MC 5100, Chicago, Illinois 60637, USA.

Journal volume & issue: Vol. 5, no. 4
pp. 396 – 406

Abstract

Read online

Cardiovascular disorders are the most common cause of mortality in autosomal dominant polycystic kidney disease (ADPKD). This review considers recent clinical and basic science studies that address the contributing factors of cardiovascular dysfunction in ADPKD. In particular, attention is placed on how dysfunction of the polycystin proteins located in the cardiovascular system contributes to extrarenal manifestations of ADPKD. Keywords: cardiovascular dysfunction, calcium signaling, heart failure, polycystic kidney disease

Published in Kidney International Reports

ISSN: 2468-0249 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the genitourinary system. Urology
Website: http://www.journals.elsevier.com/kidney-international-reports/

About the journal