Palladium-catalyzed regio- and enantioselective migratory allylic C(sp3)-H functionalization

Abstract

Alkene isomerizations and asymmetric C–H functionalizations have been independently studied, but their combination in one protocol is uncommon. Here the authors show a palladium-catalyzed method to iteratively “walk” a terminal alkene along a carbon chain to a position next to styrenes where a soft nucleophile is added asymmetrically.