Emerging Natural-Product-Based Treatments for the Management of Osteoarthritis
Maria-Luisa Pérez-Lozano,
Annabelle Cesaro,
Marija Mazor,
Eric Esteve,
Sabine Berteina-Raboin,
Thomas M. Best,
Eric Lespessailles,
Hechmi Toumi
Affiliations
Maria-Luisa Pérez-Lozano
Laboratory I3MTO, EA 4708, Université d’Orléans, CEDEX 2, 45067 Orléans, France
Annabelle Cesaro
Laboratory I3MTO, EA 4708, Université d’Orléans, CEDEX 2, 45067 Orléans, France
Marija Mazor
Center for Proteomics, Department for Histology and Embryology, Faculty of Medicine, University of Rijeka, B. Branchetta 20, 51000 Rijeka, Croatia
Eric Esteve
Service de Dermatologie, Centre Hospitalier Régional d′Orléans, 14 Avenue de l’Hôpital, 45100 Orléans, France
Sabine Berteina-Raboin
Institut de Chimie Organique et Analytique ICOA, Université d’Orléans-Pôle de Chimie, UMR CNRS 7311, Rue de Chartres-BP 6759, CEDEX 2, 45067 Orléans, France
Thomas M. Best
Department of Orthopedics, Division of Sports Medicine, Health Sports Medicine Institute, University of Miami, Coral Gables, FL 33146, USA
Eric Lespessailles
Laboratory I3MTO, EA 4708, Université d’Orléans, CEDEX 2, 45067 Orléans, France
Hechmi Toumi
Laboratory I3MTO, EA 4708, Université d’Orléans, CEDEX 2, 45067 Orléans, France
Osteoarthritis (OA) is a complex degenerative disease in which joint homeostasis is disrupted, leading to synovial inflammation, cartilage degradation, subchondral bone remodeling, and resulting in pain and joint disability. Yet, the development of new treatment strategies to restore the equilibrium of the osteoarthritic joint remains a challenge. Numerous studies have revealed that dietary components and/or natural products have anti-inflammatory, antioxidant, anti-bone-resorption, and anabolic potential and have received much attention toward the development of new therapeutic strategies for OA treatment. In the present review, we provide an overview of current and emerging natural-product-based research treatments for OA management by drawing attention to experimental, pre-clinical, and clinical models. Herein, we review current and emerging natural-product-based research treatments for OA management.
