Breast Cancer and HIV in Sub-Saharan Africa: A Complex Relationship

Surbhi Grover; Yehoda M. Martei; Priya Puri; Pooja Prabhakar; Miriam Mutebi; Onyinye D. Balogun; Aryeh J. Price; Alexandra H. Freeman; Mohan Narasimhamurthy; Danielle Rodin; Sarah Rayne; Nicola M. Zetola

doi:10.1200/JGO.2016.006585

Journal of Global Oncology (Dec 2018)

Breast Cancer and HIV in Sub-Saharan Africa: A Complex Relationship

Surbhi Grover,
Yehoda M. Martei,
Priya Puri,
Pooja Prabhakar,
Miriam Mutebi,
Onyinye D. Balogun,
Aryeh J. Price,
Alexandra H. Freeman,
Mohan Narasimhamurthy,
Danielle Rodin,
Sarah Rayne,
Nicola M. Zetola

Affiliations

Surbhi Grover: Surbhi Grover, Yehoda M. Martei, Priya Puri, and Nicola M. Zetola, University of Pennsylvania, Philadelphia, PA; Surbhi Grover, Mohan Narasimhamurthy, and Nicola M. Zetola, University of Botswana, Gaborone, Botswana; Pooja Prabhakar, University of Texas Southwestern Medical Center, Dallas, TX; Miriam Mutebi, Aga Khan University Hospital, Nairobi, Kenya; Onyinye D. Balogun, Weill Cornell Medicine, New York, NY; Aryeh J. Price, California Institute of Technology, Pasadena; Alexandra H. Freeman, Kaiser Permanente San Francisco, San Francisco, CA; Danielle Rodin, University of Toronto, Toronto, Canada; and Sarah Rayne, Helen Joseph Hospital and University of the Witwatersrand, Johannesburg, South Africa.
Yehoda M. Martei: Surbhi Grover, Yehoda M. Martei, Priya Puri, and Nicola M. Zetola, University of Pennsylvania, Philadelphia, PA; Surbhi Grover, Mohan Narasimhamurthy, and Nicola M. Zetola, University of Botswana, Gaborone, Botswana; Pooja Prabhakar, University of Texas Southwestern Medical Center, Dallas, TX; Miriam Mutebi, Aga Khan University Hospital, Nairobi, Kenya; Onyinye D. Balogun, Weill Cornell Medicine, New York, NY; Aryeh J. Price, California Institute of Technology, Pasadena; Alexandra H. Freeman, Kaiser Permanente San Francisco, San Francisco, CA; Danielle Rodin, University of Toronto, Toronto, Canada; and Sarah Rayne, Helen Joseph Hospital and University of the Witwatersrand, Johannesburg, South Africa.
Priya Puri: Surbhi Grover, Yehoda M. Martei, Priya Puri, and Nicola M. Zetola, University of Pennsylvania, Philadelphia, PA; Surbhi Grover, Mohan Narasimhamurthy, and Nicola M. Zetola, University of Botswana, Gaborone, Botswana; Pooja Prabhakar, University of Texas Southwestern Medical Center, Dallas, TX; Miriam Mutebi, Aga Khan University Hospital, Nairobi, Kenya; Onyinye D. Balogun, Weill Cornell Medicine, New York, NY; Aryeh J. Price, California Institute of Technology, Pasadena; Alexandra H. Freeman, Kaiser Permanente San Francisco, San Francisco, CA; Danielle Rodin, University of Toronto, Toronto, Canada; and Sarah Rayne, Helen Joseph Hospital and University of the Witwatersrand, Johannesburg, South Africa.
Pooja Prabhakar: Surbhi Grover, Yehoda M. Martei, Priya Puri, and Nicola M. Zetola, University of Pennsylvania, Philadelphia, PA; Surbhi Grover, Mohan Narasimhamurthy, and Nicola M. Zetola, University of Botswana, Gaborone, Botswana; Pooja Prabhakar, University of Texas Southwestern Medical Center, Dallas, TX; Miriam Mutebi, Aga Khan University Hospital, Nairobi, Kenya; Onyinye D. Balogun, Weill Cornell Medicine, New York, NY; Aryeh J. Price, California Institute of Technology, Pasadena; Alexandra H. Freeman, Kaiser Permanente San Francisco, San Francisco, CA; Danielle Rodin, University of Toronto, Toronto, Canada; and Sarah Rayne, Helen Joseph Hospital and University of the Witwatersrand, Johannesburg, South Africa.
Miriam Mutebi: Surbhi Grover, Yehoda M. Martei, Priya Puri, and Nicola M. Zetola, University of Pennsylvania, Philadelphia, PA; Surbhi Grover, Mohan Narasimhamurthy, and Nicola M. Zetola, University of Botswana, Gaborone, Botswana; Pooja Prabhakar, University of Texas Southwestern Medical Center, Dallas, TX; Miriam Mutebi, Aga Khan University Hospital, Nairobi, Kenya; Onyinye D. Balogun, Weill Cornell Medicine, New York, NY; Aryeh J. Price, California Institute of Technology, Pasadena; Alexandra H. Freeman, Kaiser Permanente San Francisco, San Francisco, CA; Danielle Rodin, University of Toronto, Toronto, Canada; and Sarah Rayne, Helen Joseph Hospital and University of the Witwatersrand, Johannesburg, South Africa.
Onyinye D. Balogun: Surbhi Grover, Yehoda M. Martei, Priya Puri, and Nicola M. Zetola, University of Pennsylvania, Philadelphia, PA; Surbhi Grover, Mohan Narasimhamurthy, and Nicola M. Zetola, University of Botswana, Gaborone, Botswana; Pooja Prabhakar, University of Texas Southwestern Medical Center, Dallas, TX; Miriam Mutebi, Aga Khan University Hospital, Nairobi, Kenya; Onyinye D. Balogun, Weill Cornell Medicine, New York, NY; Aryeh J. Price, California Institute of Technology, Pasadena; Alexandra H. Freeman, Kaiser Permanente San Francisco, San Francisco, CA; Danielle Rodin, University of Toronto, Toronto, Canada; and Sarah Rayne, Helen Joseph Hospital and University of the Witwatersrand, Johannesburg, South Africa.
Aryeh J. Price: Surbhi Grover, Yehoda M. Martei, Priya Puri, and Nicola M. Zetola, University of Pennsylvania, Philadelphia, PA; Surbhi Grover, Mohan Narasimhamurthy, and Nicola M. Zetola, University of Botswana, Gaborone, Botswana; Pooja Prabhakar, University of Texas Southwestern Medical Center, Dallas, TX; Miriam Mutebi, Aga Khan University Hospital, Nairobi, Kenya; Onyinye D. Balogun, Weill Cornell Medicine, New York, NY; Aryeh J. Price, California Institute of Technology, Pasadena; Alexandra H. Freeman, Kaiser Permanente San Francisco, San Francisco, CA; Danielle Rodin, University of Toronto, Toronto, Canada; and Sarah Rayne, Helen Joseph Hospital and University of the Witwatersrand, Johannesburg, South Africa.
Alexandra H. Freeman: Surbhi Grover, Yehoda M. Martei, Priya Puri, and Nicola M. Zetola, University of Pennsylvania, Philadelphia, PA; Surbhi Grover, Mohan Narasimhamurthy, and Nicola M. Zetola, University of Botswana, Gaborone, Botswana; Pooja Prabhakar, University of Texas Southwestern Medical Center, Dallas, TX; Miriam Mutebi, Aga Khan University Hospital, Nairobi, Kenya; Onyinye D. Balogun, Weill Cornell Medicine, New York, NY; Aryeh J. Price, California Institute of Technology, Pasadena; Alexandra H. Freeman, Kaiser Permanente San Francisco, San Francisco, CA; Danielle Rodin, University of Toronto, Toronto, Canada; and Sarah Rayne, Helen Joseph Hospital and University of the Witwatersrand, Johannesburg, South Africa.
Mohan Narasimhamurthy: Surbhi Grover, Yehoda M. Martei, Priya Puri, and Nicola M. Zetola, University of Pennsylvania, Philadelphia, PA; Surbhi Grover, Mohan Narasimhamurthy, and Nicola M. Zetola, University of Botswana, Gaborone, Botswana; Pooja Prabhakar, University of Texas Southwestern Medical Center, Dallas, TX; Miriam Mutebi, Aga Khan University Hospital, Nairobi, Kenya; Onyinye D. Balogun, Weill Cornell Medicine, New York, NY; Aryeh J. Price, California Institute of Technology, Pasadena; Alexandra H. Freeman, Kaiser Permanente San Francisco, San Francisco, CA; Danielle Rodin, University of Toronto, Toronto, Canada; and Sarah Rayne, Helen Joseph Hospital and University of the Witwatersrand, Johannesburg, South Africa.
Danielle Rodin: Surbhi Grover, Yehoda M. Martei, Priya Puri, and Nicola M. Zetola, University of Pennsylvania, Philadelphia, PA; Surbhi Grover, Mohan Narasimhamurthy, and Nicola M. Zetola, University of Botswana, Gaborone, Botswana; Pooja Prabhakar, University of Texas Southwestern Medical Center, Dallas, TX; Miriam Mutebi, Aga Khan University Hospital, Nairobi, Kenya; Onyinye D. Balogun, Weill Cornell Medicine, New York, NY; Aryeh J. Price, California Institute of Technology, Pasadena; Alexandra H. Freeman, Kaiser Permanente San Francisco, San Francisco, CA; Danielle Rodin, University of Toronto, Toronto, Canada; and Sarah Rayne, Helen Joseph Hospital and University of the Witwatersrand, Johannesburg, South Africa.
Sarah Rayne: Surbhi Grover, Yehoda M. Martei, Priya Puri, and Nicola M. Zetola, University of Pennsylvania, Philadelphia, PA; Surbhi Grover, Mohan Narasimhamurthy, and Nicola M. Zetola, University of Botswana, Gaborone, Botswana; Pooja Prabhakar, University of Texas Southwestern Medical Center, Dallas, TX; Miriam Mutebi, Aga Khan University Hospital, Nairobi, Kenya; Onyinye D. Balogun, Weill Cornell Medicine, New York, NY; Aryeh J. Price, California Institute of Technology, Pasadena; Alexandra H. Freeman, Kaiser Permanente San Francisco, San Francisco, CA; Danielle Rodin, University of Toronto, Toronto, Canada; and Sarah Rayne, Helen Joseph Hospital and University of the Witwatersrand, Johannesburg, South Africa.
Nicola M. Zetola: Surbhi Grover, Yehoda M. Martei, Priya Puri, and Nicola M. Zetola, University of Pennsylvania, Philadelphia, PA; Surbhi Grover, Mohan Narasimhamurthy, and Nicola M. Zetola, University of Botswana, Gaborone, Botswana; Pooja Prabhakar, University of Texas Southwestern Medical Center, Dallas, TX; Miriam Mutebi, Aga Khan University Hospital, Nairobi, Kenya; Onyinye D. Balogun, Weill Cornell Medicine, New York, NY; Aryeh J. Price, California Institute of Technology, Pasadena; Alexandra H. Freeman, Kaiser Permanente San Francisco, San Francisco, CA; Danielle Rodin, University of Toronto, Toronto, Canada; and Sarah Rayne, Helen Joseph Hospital and University of the Witwatersrand, Johannesburg, South Africa.

DOI: https://doi.org/10.1200/JGO.2016.006585
Journal volume & issue: no. 4
pp. 1 – 11

Abstract

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Introduction The number and lifespan of individuals living with HIV have increased significantly with the scale-up of antiretroviral therapy. Furthermore, the incidence of breast cancer in women with HIV is growing, especially in sub-Saharan Africa (SSA). However, the association between HIV infection and breast cancer is not well understood. Methods A literature search was performed to identify articles published in journals pertaining to breast cancer and HIV, with an emphasis on SSA. Selected US-based studies were also identified for comparison. Results Among the 56 studies reviewed, the largest study examined 314 patients with breast cancer and HIV in the United States. There is no consensus on whether HIV infection acts as a pro-oncogenic or antioncogenic factor in breast cancer, and it may have no relation to breast cancer. A higher incidence of breast cancer is reported in high-income countries than in SSA, although breast cancer in SSA presents at a younger age and at a more advanced stage. Some studies show that patients with breast cancer and HIV experience worse chemotherapy toxicity than do patients without HIV. Data on treatment outcomes are limited. The largest study showed worse treatment outcomes in patients with HIV, compared with their counterparts without HIV. Conclusion HIV infection has not been associated with different clinical presentation of breast cancer. However, some evidence suggests that concurrent diagnosis of HIV with breast cancer is associated with increased therapy-related toxicity and worse outcomes. Systematic prospective studies are needed to establish whether there is a specific association between breast cancer and HIV.

Published in Journal of Global Oncology

ISSN: 2378-9506 (Online)
Publisher: American Society of Clinical Oncology
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://ascopubs.org/journal/jgo

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