Communications Physics (Aug 2021)

Asymmetric binomial statistics explains organelle partitioning variance in cancer cell proliferation

  • Giovanna Peruzzi,
  • Mattia Miotto,
  • Roberta Maggio,
  • Giancarlo Ruocco,
  • Giorgio Gosti

Journal volume & issue
Vol. 4, no. 1
pp. 1 – 12


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Emerging experimental observation suggests that asymmetrical partitioning in cell division plays an important role in cell-to-cell variability, cell fate determination, cellular aging, and rejuvenation. Here, the authors propose a method based on multicolor flow cytometry to measure asymmetric division of cellular organelles, finding that cell cytoplasm is divided symmetrically but mitochondria and membrane lipids are asymmetrically distributed, and explain these observations through a minimal model of asymmetric partitioning based on biased binomial statistics.