WASH maintains NKp46+ ILC3 cells by promoting AHR expression

Pengyan Xia; Jing Liu; Shuo Wang; Buqing Ye; Ying Du; Zhen Xiong; Ze-Guang Han; Liang Tong; Zusen Fan

doi:10.1038/ncomms15685

Nature Communications (Jun 2017)

WASH maintains NKp46+ ILC3 cells by promoting AHR expression

Pengyan Xia,
Jing Liu,
Shuo Wang,
Buqing Ye,
Ying Du,
Zhen Xiong,
Ze-Guang Han,
Liang Tong,
Zusen Fan

Affiliations

Pengyan Xia: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Jing Liu: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Shuo Wang: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Buqing Ye: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Ying Du: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Zhen Xiong: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Ze-Guang Han: Key Laboratory of Systems Biomedicine (Ministry of Education) and Collaborative Innovation Center of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University
Liang Tong: Department of Biological Sciences, Columbia University
Zusen Fan: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/ncomms15685
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

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Innate lymphoid cells (ILC) are thought to direct immune responses, but little is known about the development and maintenance of ILC subsets. Here the authors show that WASH maintains the pool of NKp46+ ILC3s by recruiting Arid1a to the aryl hydrocarbon receptor promoter and inducing its expression.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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