Neuropsychiatric Disease and Treatment (Jan 2023)

Correlations Between Serum CXCL9/12 and the Severity of Acute Ischemic Stroke, a Retrospective Observational Study

  • Han M,
  • Ma B,
  • She R,
  • Xing Y,
  • Li X

Journal volume & issue
Vol. Volume 19
pp. 283 – 292

Abstract

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Miaomiao Han,1,2 Bo Ma,3 Ruifang She,4 Yan Xing,5 Xiaohong Li1 1Department of Neurology, Jinan Central Hospital, Shandong University, Jinan City, People’s Republic of China; 2Encephalopathy Department, Zibo Hospital of Integrated Traditional Chinese and Western Medicine, Zibo City, People’s Republic of China; 3Department of Neurology, The First Affiliated Hospital of Bengbu Medical College, Bengbu City, People’s Republic of China; 4Department of Neurology, Tai’ an City Central Hospital, Tai’ an City, People’s Republic of China; 5Zibo Center for Disease Control and Prevention, Zibo City, People’s Republic of ChinaCorrespondence: Xiaohong Li, Department of Neurology, Jinan Central Hospital, Shandong University, No. 105, Jiefang Road, Jinan City, Shandong Province, 250013, People’s Republic of China, Tel + 86 13370582096, Email [email protected]: This retrospective observational study was conducted to determine the correlations between serum CXCL9/12 and the severity of acute ischemic stroke (AIS).Methods: Total 138 patients with AIS were enrolled in the study. These patients underwent Brain CT on admission and blood samples were collected. Serum CXCL9 and CXCL12 were detected by ELISA assay. The correlations of serum CXCL9/12 with AIS was analyzed based on Oxfordshire Community Stroke Project (OCSP) classification, Trial of Org 10,172 in acute stroke treatment (TOAST) classification, National Institutes of Health Stroke Score (NIHSS) score, infarct volume, and modified Rankin scale (mRS) score.Results: Compared with the controls, patients with AIS had higher levels of serum CXCL9 and CXCL12. Logistic regression analysis determined that CXCL9 and CXCL12 were independent risk factors for AIS. In addition, the increased serum CXCL9 and CXCL12 were associated with TOAST classification, NIHSS score, and infarct volume. However, serum CXCL9 and CXCL12 were not associated with functional outcomes (mRS score). CXCL9 and CXCL12 both exhibited a high diagnostic value in AIS.Conclusion: Serum CXCL9 and CXCL12 were elevated in patients with AIS, closely correlated with the severity of AIS.Keywords: acute ischemic stroke, CXCL9, CXCL12, stroke severity, NIHSS score

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