Nature Communications (Aug 2019)

CSL controls telomere maintenance and genome stability in human dermal fibroblasts

  • Giulia Bottoni,
  • Atul Katarkar,
  • Beatrice Tassone,
  • Soumitra Ghosh,
  • Andrea Clocchiatti,
  • Sandro Goruppi,
  • Pino Bordignon,
  • Paris Jafari,
  • Fabio Tordini,
  • Thomas Lunardi,
  • Wolfram Hoetzenecker,
  • Victor Neel,
  • Joachim Lingner,
  • G. Paolo Dotto

DOI
https://doi.org/10.1038/s41467-019-11785-7
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

Read online

Conversion of dermal fibroblasts into Cancer Associated Fibroblasts (CAFs) can play an important role in keratinocyte tumour development. Here the authors reveal that CSL plays a role in maintenance of telomeres and genomic integrity in both dermal fibroblasts and CAFs.