Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications

Hui Wang; Hongyi Zhang; Yihao Zhu; Zhonghang Wu; Zhonghang Wu; Chunhong Cui; Chunhong Cui; Fengfeng Cai

doi:10.3389/fonc.2021.654428

Frontiers in Oncology (Jul 2021)

Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications

Hui Wang,
Hongyi Zhang,
Yihao Zhu,
Zhonghang Wu,
Zhonghang Wu,
Chunhong Cui,
Chunhong Cui,
Fengfeng Cai

Affiliations

Hui Wang: Laboratory of Tumor Molecular Biology, School of Basic Medical Sciences, Shanghai University of Medicine and Health Sciences, Shanghai, China
Hongyi Zhang: Department of Breast Surgery, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China
Yihao Zhu: Laboratory of Tumor Molecular Biology, School of Basic Medical Sciences, Shanghai University of Medicine and Health Sciences, Shanghai, China
Zhonghang Wu: Department of Scientific Research, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China
Zhonghang Wu: Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China
Chunhong Cui: Laboratory of Tumor Molecular Biology, School of Basic Medical Sciences, Shanghai University of Medicine and Health Sciences, Shanghai, China
Chunhong Cui: Department of Scientific Research, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China
Fengfeng Cai: Department of Breast Surgery, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China

DOI: https://doi.org/10.3389/fonc.2021.654428
Journal volume & issue: Vol. 11

Abstract

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Breast cancer (BC) is the most frequent cancer among women worldwide and is the leading cause of cancer-related deaths in women. Cancer cells with stem cell-like features and tumor-initiating potential contribute to drug resistance, tumor recurrence, and metastasis. To achieve better clinical outcomes, it is crucial to eradicate both bulk BC cells and breast cancer stem cells (BCSCs). Salinomycin, a monocarboxylic polyether antibiotic isolated from Streptomyces albus, can precisely kill cancer stem cells (CSCs), particularly BCSCs, by various mechanisms, including apoptosis, autophagy, and necrosis. There is increasing evidence that salinomycin can inhibit cell proliferation, invasion, and migration in BC and reverse the immune-inhibitory microenvironment to prevent tumor growth and metastasis. Therefore, salinomycin is a promising therapeutic drug for BC. In this review, we summarize established mechanisms by which salinomycin protects against BC and discuss its future clinical applications.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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Abstract

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