Biomolecules (Mar 2021)

Insights from Cardiopulmonary Exercise Testing in Pediatric Patients with Hypertrophic Cardiomyopathy

  • Giovanna Gallo,
  • Vittoria Mastromarino,
  • Giuseppe Limongelli,
  • Giulio Calcagni,
  • Antonello Maruotti,
  • Luca Ragni,
  • Fabio Valente,
  • Maria Beatrice Musumeci,
  • Rachele Adorisio,
  • Marta Rubino,
  • Camillo Autore,
  • Damiano Magrì

DOI
https://doi.org/10.3390/biom11030376
Journal volume & issue
Vol. 11, no. 3
p. 376

Abstract

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The usefulness of cardiopulmonary exercise test (CPET) in adult hypertrophic cardiomyopathy (HCM) patients is well-known, whereas its role in pediatric HCM patients has not yet been explored. The present study investigates possible insights from a CPET assessment in a cohort of pediatric HCM outpatients in terms of functional and prognostic assessment. Sixty consecutive pediatric HCM outpatients aged 2) values of 2% was the variable with the strongest association with adverse events at follow-up (C-index = 0.72, p = 0.025) and a cut-off value equal to 60% was the most accurate in identifying those patients at the highest risk. In a pediatric HCM subset, the CPET assessment allows a true functional capacity estimation and it might be helpful in identifying early those patients at high risk of events.

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