Frontiers in Oncology (Nov 2021)
Functional Peptides Encoded by Long Non-Coding RNAs in Gastrointestinal Cancer
- Yao Chen,
- Yao Chen,
- Yao Chen,
- Weili Long,
- Liqiong Yang,
- Liqiong Yang,
- Liqiong Yang,
- Yueshui Zhao,
- Yueshui Zhao,
- Yueshui Zhao,
- Xu Wu,
- Xu Wu,
- Xu Wu,
- Mingxing Li,
- Mingxing Li,
- Mingxing Li,
- Fukuan Du,
- Fukuan Du,
- Fukuan Du,
- Yu Chen,
- Yu Chen,
- Yu Chen,
- Zhihui Yang,
- Qinglian Wen,
- Tao Yi,
- Zhangang Xiao,
- Zhangang Xiao,
- Zhangang Xiao,
- Jing Shen,
- Jing Shen,
- Jing Shen
Affiliations
- Yao Chen
- Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China
- Yao Chen
- South Sichuan Institute of Translational Medicine, Luzhou, China
- Yao Chen
- Laboratory of Personalised Cell Therapy & Cell Medicines, School of Pharmacy, Southwest Medical University, Luzhou, China
- Weili Long
- School of Basic Medicine, Southwest Medical University, Luzhou, China
- Liqiong Yang
- Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China
- Liqiong Yang
- South Sichuan Institute of Translational Medicine, Luzhou, China
- Liqiong Yang
- Laboratory of Personalised Cell Therapy & Cell Medicines, School of Pharmacy, Southwest Medical University, Luzhou, China
- Yueshui Zhao
- Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China
- Yueshui Zhao
- South Sichuan Institute of Translational Medicine, Luzhou, China
- Yueshui Zhao
- Laboratory of Personalised Cell Therapy & Cell Medicines, School of Pharmacy, Southwest Medical University, Luzhou, China
- Xu Wu
- Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China
- Xu Wu
- South Sichuan Institute of Translational Medicine, Luzhou, China
- Xu Wu
- Laboratory of Personalised Cell Therapy & Cell Medicines, School of Pharmacy, Southwest Medical University, Luzhou, China
- Mingxing Li
- Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China
- Mingxing Li
- South Sichuan Institute of Translational Medicine, Luzhou, China
- Mingxing Li
- Laboratory of Personalised Cell Therapy & Cell Medicines, School of Pharmacy, Southwest Medical University, Luzhou, China
- Fukuan Du
- Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China
- Fukuan Du
- South Sichuan Institute of Translational Medicine, Luzhou, China
- Fukuan Du
- Laboratory of Personalised Cell Therapy & Cell Medicines, School of Pharmacy, Southwest Medical University, Luzhou, China
- Yu Chen
- Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China
- Yu Chen
- South Sichuan Institute of Translational Medicine, Luzhou, China
- Yu Chen
- Laboratory of Personalised Cell Therapy & Cell Medicines, School of Pharmacy, Southwest Medical University, Luzhou, China
- Zhihui Yang
- Department of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, China
- Qinglian Wen
- Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, China
- Tao Yi
- School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, Hong Kong SAR, China
- Zhangang Xiao
- Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China
- Zhangang Xiao
- South Sichuan Institute of Translational Medicine, Luzhou, China
- Zhangang Xiao
- Laboratory of Personalised Cell Therapy & Cell Medicines, School of Pharmacy, Southwest Medical University, Luzhou, China
- Jing Shen
- Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China
- Jing Shen
- South Sichuan Institute of Translational Medicine, Luzhou, China
- Jing Shen
- Laboratory of Personalised Cell Therapy & Cell Medicines, School of Pharmacy, Southwest Medical University, Luzhou, China
- DOI
- https://doi.org/10.3389/fonc.2021.777374
- Journal volume & issue
-
Vol. 11
Abstract
Gastrointestinal cancer is by far the most common malignancy and the most common cause of cancer-related deaths worldwide. Recent studies have shown that long non-coding RNAs (lncRNAs) play an important role in the epigenetic regulation of cancer cells and regulate tumor progression by affecting chromatin modifications, gene transcription, translation, and sponge to miRNAs. In particular, lncRNA has recently been found to possess open reading frame (ORF), which can encode functional small peptides or proteins. These peptides interact with its targets to regulate transcription or the signal axis, thus promoting or inhibiting the occurrence and development of tumors. In this review, we summarize the involvement of lncRNAs and the function of lncRNAs encoded small peptides in gastrointestinal cancer.
Keywords
