Synthesis and Inhibition of Influenza H1N1 Virus by Indolo-Glycyrrhetic Acid Cyanoesters
Anastasiya V. Petrova,
Svetlana V. Belyaevskaya,
Vladimir V. Zarubaev
Affiliations
Anastasiya V. Petrova
Ufa Institute of Chemistry, Ufa Federal Research Centre, Russian Academy of Sciences, 71, Prospect Octyabrya, 450054 Ufa, Russia
Svetlana V. Belyaevskaya
Experimental Virology Laboratory, Department of Virology, St. Petersburg Pasteur Institute of Epidemiology and Microbiology, 14 Mira St., 197001 St. Petersburg, Russia
Vladimir V. Zarubaev
Experimental Virology Laboratory, Department of Virology, St. Petersburg Pasteur Institute of Epidemiology and Microbiology, 14 Mira St., 197001 St. Petersburg, Russia
Two new indolo-glycyrrhetic acid derivatives containing cyano-substitutent at C30 have been synthesized, and their anti-influenza activity has been evaluated in vitro. The resulting data demonstrated moderate inhibitory activity against the H1N1 virus with IC50 29 and 23 μM, respectively. The value of SI 18 and 21 confirm low toxicity and potential of new compounds for following research and development of new biological agents.
