Efficacy of simultaneous VEGF‐A/ANG‐2 neutralization in suppressing spontaneous choroidal neovascularization

Abstract

Graphical Abstract This study independently confirms in vivo in the JR5558 mouse model of aberrant retinal angiogenesis, that simultaneous VEGF‐A and ANG‐2 neutralization using a bispecific anti‐VEGF‐A/ANG‐2 antibody reduces vascular leakage, immune reactivity and apoptosis more effectively than either agent alone.