Paternal low protein diet perturbs inter-generational metabolic homeostasis in a tissue-specific manner in mice

Hannah L. Morgan; Samuel Furse; Irundika H. K. Dias; Kiran Shabir; Marcos Castellanos; Iqbal Khan; Sean T. May; Nadine Holmes; Matthew Carlile; Fei Sang; Victoria Wright; Albert Koulman; Adam J. Watkins

doi:10.1038/s42003-022-03914-8

Communications Biology (Sep 2022)

Paternal low protein diet perturbs inter-generational metabolic homeostasis in a tissue-specific manner in mice

Hannah L. Morgan,
Samuel Furse,
Irundika H. K. Dias,
Kiran Shabir,
Marcos Castellanos,
Iqbal Khan,
Sean T. May,
Nadine Holmes,
Matthew Carlile,
Fei Sang,
Victoria Wright,
Albert Koulman,
Adam J. Watkins

Affiliations

Hannah L. Morgan: Lifespan and Population Health, School of Medicine, University of Nottingham
Samuel Furse: Core Metabolomics and Lipidomics Laboratory, Wellcome-MRC Institute of Metabolic Science, University of Cambridge
Irundika H. K. Dias: Aston Medical School, Aston University, Aston Triangle
Kiran Shabir: Aston Medical School, Aston University, Aston Triangle
Marcos Castellanos: Nottingham Arabidopsis Stock Centre (NASC), University of Nottingham, Sutton Bonington Campus, Plant Science Building, School of Biosciences
Iqbal Khan: Nottingham Arabidopsis Stock Centre (NASC), University of Nottingham, Sutton Bonington Campus, Plant Science Building, School of Biosciences
Sean T. May: Nottingham Arabidopsis Stock Centre (NASC), University of Nottingham, Sutton Bonington Campus, Plant Science Building, School of Biosciences
Nadine Holmes: Deep Seq, School of Life Sciences, Queen’s Medical Centre, University of Nottingham
Matthew Carlile: Deep Seq, School of Life Sciences, Queen’s Medical Centre, University of Nottingham
Fei Sang: Deep Seq, School of Life Sciences, Queen’s Medical Centre, University of Nottingham
Victoria Wright: Deep Seq, School of Life Sciences, Queen’s Medical Centre, University of Nottingham
Albert Koulman: Core Metabolomics and Lipidomics Laboratory, Wellcome-MRC Institute of Metabolic Science, University of Cambridge
Adam J. Watkins: Lifespan and Population Health, School of Medicine, University of Nottingham

DOI: https://doi.org/10.1038/s42003-022-03914-8
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 12

Abstract

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Poor paternal diet leads to changes in offspring tissue lipid abundance that is still evident in a second generation.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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