Huang Qi Tong Bi Decoction Attenuates Myocardial Ischemia-Reperfusion Injury via HMGB1/TLR/NF-κB Pathway

Kun Liu; Manman Li; Xiumei Ren; Qing-sheng You; Fei Wang; Shuo Wang; Chun-Hui Ma; Wei-Nan Li; Qing Ye

doi:10.1155/2019/8387636

Mediators of Inflammation (Jan 2019)

Huang Qi Tong Bi Decoction Attenuates Myocardial Ischemia-Reperfusion Injury via HMGB1/TLR/NF-κB Pathway

Kun Liu,
Manman Li,
Xiumei Ren,
Qing-sheng You,
Fei Wang,
Shuo Wang,
Chun-Hui Ma,
Wei-Nan Li,
Qing Ye

Affiliations

Kun Liu: Department of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Nantong, China
Manman Li: School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China
Xiumei Ren: Department of Traditional Chinese Medicine, Affiliated Hospital of Nantong University, Nantong, China
Qing-sheng You: Department of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Nantong, China
Fei Wang: Department of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Nantong, China
Shuo Wang: Department of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Nantong, China
Chun-Hui Ma: Department of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Nantong, China
Wei-Nan Li: Department of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Nantong, China
Qing Ye: Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Nantong, China

DOI: https://doi.org/10.1155/2019/8387636
Journal volume & issue: Vol. 2019

Abstract

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The aim of this study was to study the protective effect of Huang Qi Tong Bi Decoction (HQTBT) on the heart of rats. Ischemia-reperfusion injury was established by coronary artery ligation. Proinflammatory cytokines were decreased by XFZY in coronary artery ligated rats. ST segment was also restored with the treatment of HQTBT. Triphenyltetrazole chloride (TTC) staining and pathological analysis showed that HQTBT reduced myocardial injury. Besides, the expressions of HMGB1/TLR/NF-κB pathway in rats were significantly decreased by HQTBT. This study shows that HQTBT inhibited inflammatory reaction on myocardial injury in rats.

Published in Mediators of Inflammation

ISSN: 0962-9351 (Print); 1466-1861 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Pathology
Website: https://www.hindawi.com/journals/mi/

About the journal