Nature Communications (Apr 2022)
Glutathione-dependent redox balance characterizes the distinct metabolic properties of follicular and marginal zone B cells
- Davide G. Franchina,
- Henry Kurniawan,
- Melanie Grusdat,
- Carole Binsfeld,
- Luana Guerra,
- Lynn Bonetti,
- Leticia Soriano-Baguet,
- Anouk Ewen,
- Takumi Kobayashi,
- Sophie Farinelle,
- Anna Rita Minafra,
- Niels Vandamme,
- Anaïs Carpentier,
- Felix K. Borgmann,
- Christian Jäger,
- Ying Chen,
- Markus Kleinewietfeld,
- Vasilis Vasiliou,
- Michel Mittelbronn,
- Karsten Hiller,
- Philipp A. Lang,
- Dirk Brenner
Affiliations
- Davide G. Franchina
- Experimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health
- Henry Kurniawan
- Experimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health
- Melanie Grusdat
- Experimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health
- Carole Binsfeld
- Experimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health
- Luana Guerra
- Experimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health
- Lynn Bonetti
- Experimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health
- Leticia Soriano-Baguet
- Experimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health
- Anouk Ewen
- Experimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health
- Takumi Kobayashi
- Experimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health
- Sophie Farinelle
- Experimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health
- Anna Rita Minafra
- Department of Molecular Medicine II, Medical Faculty, Heinrich-Heine-University
- Niels Vandamme
- National Data Mining and Modelling for Biomedicine, VIB Center for Inflammation Research
- Anaïs Carpentier
- National Center of Pathology (NCP), Laboratoire National de Santé (LNS)
- Felix K. Borgmann
- National Center of Pathology (NCP), Laboratoire National de Santé (LNS)
- Christian Jäger
- Luxembourg Centre for Systems Biomedicine, University of Luxembourg
- Ying Chen
- Department of Environmental Health Sciences, Yale School of Public Health
- Markus Kleinewietfeld
- VIB Laboratory of Translational Immunomodulation, VIB Center for Inflammation Research (IRC) Hasselt University
- Vasilis Vasiliou
- Department of Environmental Health Sciences, Yale School of Public Health
- Michel Mittelbronn
- National Center of Pathology (NCP), Laboratoire National de Santé (LNS)
- Karsten Hiller
- Department for Bioinformatics and Biochemistry, Braunschweig Integrated Center of Systems Biology (BRICS), Technische Universität Braunschweig
- Philipp A. Lang
- Department of Molecular Medicine II, Medical Faculty, Heinrich-Heine-University
- Dirk Brenner
- Experimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health
- DOI
- https://doi.org/10.1038/s41467-022-29426-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 21
Abstract
Follicular and marginal zone B (FoB and MZB, respectively) cells have divergent metabolic characteristics. Here the authors show that deficiency of glutamate cysteine ligase (Gclc), the enzyme for glutathione synthesis, differentially impacts FoB and MZB homeostasis, while specifically impeding FoB activation and downstream antiviral immunity.
