Archives of Biological Sciences (Jan 2006)

Cytogenetic diepoxybutane sensitivity in Serbian children with Fanconi anemia

  • Ćirković Sanja,
  • Guć-Šćekić Marija,
  • Vujić Dragana,
  • Mićić D.

DOI
https://doi.org/10.2298/ABS0604215C
Journal volume & issue
Vol. 58, no. 4
pp. 215 – 219

Abstract

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Fanconi anemia (FA) is an inherited disorder with aplastic anemia, cancer susceptibility, and hypersensitivity to alkylating agents such as diepoxybutane (DEB). The DEB test is used to screen for FA among patients with bone marrow failure syndromes (BMFS). From February of 2004 to May of 2006, 29 children with BMFS were diagnosed and treated at the Mother and Child Health Care Institute of Serbia (MCHIS). In the examined group, five out of 29 patients (17.2%) were found to have increased DEB-induced chromosome breakage (0.58-2.15 vs. 0.00-0.20 breaks/cell; p<0.001) with no overlap. Our results suggest the importance of this analysis for differential diagnosis and adequate therapy of FA among patients with BMFS.

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