Journal of Dental Sciences (Mar 2012)

Phenytoin- and amlodipine-induced gingival overgrowth

  • Ching-Wen Chang,
  • Chih-Jen Yang,
  • Yu-Lin Lai

DOI
https://doi.org/10.1016/j.jds.2012.01.013
Journal volume & issue
Vol. 7, no. 1
pp. 85 – 88

Abstract

Read online

Drug-induced gingival overgrowth is an adverse event associated with three types of drugs, i.e., anticonvulsants, immunosuppressants, and calcium-channel blockers. It was shown that the combined use of an immunosuppressant (cyclosporine) and a calcium-channel blocker increases the prevalence and severity of gingival overgrowth. However, few reports discussed the effects of the combination of an anticonvulsant (phenytoin) and a calcium-channel blocker (amlodipine). In this case report, we present an epilepsy patient who was using both phenytoin and amlodipine, which caused extensive gingival overgrowth. After periodontal treatment and a gingivectomy, the gingival overgrowth was significantly reduced. A postoperative drug-substitution regimen and intensive professional care ensured a stable result 1 year after surgery.

Keywords