Molecules (Jan 2023)

Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold

  • Siva S. Panda,
  • Adel S. Girgis,
  • Marian N. Aziz,
  • Mohamed S. Bekheit

DOI
https://doi.org/10.3390/molecules28020618
Journal volume & issue
Vol. 28, no. 2
p. 618

Abstract

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Spirooxindoles occupy an important place in heterocyclic chemistry. Many natural spirooxindole-containing compounds have been identified as bio-promising agents. Synthetic analogs have also been synthesized utilizing different pathways. The present article summarizes the recent development of both natural and synthetic spirooxindole-containing compounds prepared from isatin or its derivatives reported in the last five years. The spirooxindoles are categorized based on their mentioned biological properties.

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