Tripchlorolide attenuates β-amyloid generation by inducing NEP activity in N2a/APP695 cells

Zeng Yuqi; Li Yongkun; Shen Hui; Lin Nan; Zhang Jian

doi:10.1515/tnsci-2020-0178

Translational Neuroscience (Jul 2021)

Tripchlorolide attenuates β-amyloid generation by inducing NEP activity in N2a/APP695 cells

Zeng Yuqi,
Li Yongkun,
Shen Hui,
Lin Nan,
Zhang Jian

Affiliations

Zeng Yuqi: Department of Neurology, Institute of Clinical Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou, Fujian, 350001, China
Li Yongkun: Department of Neurology, Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, 361002, China
Shen Hui: Department of Geriatrics, Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou, Fujian, 350001, China
Lin Nan: Department of Geriatrics, Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou, Fujian, 350001, China
Zhang Jian: Department of Neurology, Institute of Clinical Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou, Fujian, 350001, China

DOI: https://doi.org/10.1515/tnsci-2020-0178
Journal volume & issue: Vol. 12, no. 1
pp. 301 – 308

Abstract

Read online

Alzheimer’s disease (AD) is a neurodegeneration disease. The previous work from our research group demonstrated the neuroprotective effects of tripchlorolide (T4) in AD animal models.

Published in Translational Neuroscience

ISSN: 2081-6936 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.degruyter.com/view/j/tnsci

About the journal

Abstract

Keywords