P-wave and QT interval dispersion analysis in children with Eisenmenger syndrome

Abstract

Objectives: P-wave and QT dispersion are increased and associated with atrial and ventricular arrhythmia and an increase in sudden death in a variety of diseases. This study aimed to investigate P-wave and QT dispersion in children with Eisenmenger syndrome (ES). Study design: The study group included 27 children (15 females, 12 males) with both congenital heart disease (CHD) and ES. The control group consisted of 30 children with CHD without pulmonary arterial hypertension. Electrocardiographic records were used to determine P-wave, QT, and corrected QT (QTc) dispersions. 24-hour (h) rhythm Holter was fitted in all patients. Atrial volumes, ventricular dimensions and tricuspid annular plane systolic excursion (TAPSE) were measured by echocardiography. Results: There was no difference between groups with regard to age, sex, weight, and body surface area (p>0.05). Right atrial volume was significantly larger in the ES group than in the control group. P-wave, QT and QTc dispersions were higher in the patients with ES (50.10+-11.12 vs. 26.32+-8.90, p<0.001; 57.40+-24.21 vs. 38.20+-8.92 ms, p<0.001; and 78.20+-16.02 vs. 56.52+-13.92 ms, p<0.001, respectively). Ventricular and supraventricular ectopy were significantly more frequent in the ES group. Four patients (14.8%) in the study group had tachyarrhythmias during 24-h Holter monitoring. Conclusion: In our study, P-wave and QT dispersion were found to be greater in children with ES than in the healthy control subjects.

Keywords

• arrhythmias
• cardiac/physiopathology
• heart catheterization; child; echocardiography; eisenmenger complex/complications; electrocardiography; hypertension
• pulmonary.