Nature Communications (Sep 2021)

Hypoxia regulates overall mRNA homeostasis by inducing Met1-linked linear ubiquitination of AGO2 in cancer cells

  • Hailong Zhang,
  • Xian Zhao,
  • Yanmin Guo,
  • Ran Chen,
  • Jianfeng He,
  • Lian Li,
  • Zhe Qiang,
  • Qianqian Yang,
  • Xiaojia Liu,
  • Caihu Huang,
  • Runhui Lu,
  • Jiayu Fang,
  • Yingting Cao,
  • Jiayi Huang,
  • Yanli Wang,
  • Jian Huang,
  • Guo-Qiang Chen,
  • Jinke Cheng,
  • Jianxiu Yu

DOI
https://doi.org/10.1038/s41467-021-25739-5
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 20

Abstract

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Met1-linked linear ubiquitination (M1-Ubi) is catalyzed by linear ubiquitin chain assembly complex (LUBAC). Here the authors show that Ago2 protein is M1-Ubi modified by LUBAC complex under hypoxia condition leading to less association of miRNA target mRNAs to Ago2 protein and de-repression of miRNA targets.