Prognostic predictive value of Ki-67 in stage I–II triple-negative breast cancer

Abstract

Aim: Our research aimed to determine an optimal cutoff value and investigate the prognostic predictive function of Ki-67. Materials & methods: We retrospectively enrolled 1146 patients diagnosed with stage I–II triple-negative breast cancer. Disease-free and overall survival were analyzed using the Kaplan–Meier method and the Cox regression model. Results: We classified Ki-67 >45% as the high group (n = 716). A Ki-67 level of >45% was associated with poorer disease-free survival (p = 0.039) and overall survival (p = 0.029). Lymph node stage, neoadjuvant chemotherapy, and radiotherapy were independent predictive variables of prognosis. Conclusion: Triple-negative breast cancer may be further subcategorized according to the Ki-67 level. Neoadjuvant chemotherapy and postoperative radiotherapy can improve the prognosis of early triple-negative breast cancer.

Keywords

• Ki-67
• neoadjuvant chemotherapy
• postoperative radiotherapy
• prognosis
• triple-negative breast cancer