Studies of the Synchronous Sensing Method in the Microfluidic Cell Impedance Detection

Abstract

Microfluidic impedance sensors play a significant role in point-of-care applications, clinical tests and laboratory studies. Instead of the traditional signal process method with the envelope detector, filter banks and multistage amplifier, we have reported a new implement using synchronous sampling and orthogonal detecting. By studying the intensity and phase modulation in the cell impedance sensing progress, we have calculated the SNR of the new method compare with the raw data. Base on the physical model and the calculation, we have demonstrated a simulation result which shows a capability to detect the signal of 1um cell in a noisy environment.

Keywords

• Phase
• Orthogonal wave
• Multiply-add operation
• Noise inhibition
• Synchronous sampling.