Scientific Reports (Jan 2022)

Impaired selective renal filtration captured by eGFRcysC/eGFRcrea ratio is associated with mortality in a population based cohort of older women

  • Linnea Malmgren,
  • Fiona E. McGuigan,
  • Anders Christensson,
  • Kristina E. Akesson

DOI
https://doi.org/10.1038/s41598-022-05320-w
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 8

Abstract

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Abstract Deranged renal filtration of mid-sized (5–30 kDa) compared to smaller molecules ( 0.9 (HRadj 1.6 [95% CI 1.1–2.5]). In elderly women eGFRcysC/eGFRcrea ratio < 0.6 is common and associated with increased mortality. Our results confirm patient-based findings, suggesting that identifying individuals with SPS may be clinically relevant to assessing mortality risk in the elderly.