EFFECT OF IRON ON CAPSULE BIOSYNTHESIS OF CRYPTOCOCCUS NEOFORMANS

Abstract

Ln this study several tests showed that high level of iron either in sera from patients with rheumatoid arthritis, th alassaemia major or in standard iron solutions, have inhibitory effect Oil capsule production of Cryptococcus neotormans. This work is concerned with the probable role of iron in pigeon's natural resistance against cryptococcal infection: No protease activity was detected in either capsular Of acapsularyeasts whereas high activity of p-glucufonidase was demonstrated in the only experimentally produced acapsular Olle. This suggests the porticipotion of iron in demonstrating pathogenic character oforganism and related aspects.