Association between the rs1465040 single-nucleotide polymorphism close to the transient receptor potential subfamily C member 3 (TRPC3) gene and postoperative analgesic requirements

Yoshinori Aoki; Daisuke Nishizawa; Junko Hasegawa; Shinya Kasai; Kaori Yoshida; Yoshihiko Koukita; Tatsuya Ichinohe; Makoto Nagashima; Ryoji Katoh; Yasuo Satoh; Megumi Tagami; Masakazu Hayashida; Ken-ichi Fukuda; Kazutaka Ikeda

doi:10.1016/j.jphs.2015.02.005

Journal of Pharmacological Sciences (Mar 2015)

Association between the rs1465040 single-nucleotide polymorphism close to the transient receptor potential subfamily C member 3 (TRPC3) gene and postoperative analgesic requirements

Yoshinori Aoki,
Daisuke Nishizawa,
Junko Hasegawa,
Shinya Kasai,
Kaori Yoshida,
Yoshihiko Koukita,
Tatsuya Ichinohe,
Makoto Nagashima,
Ryoji Katoh,
Yasuo Satoh,
Megumi Tagami,
Masakazu Hayashida,
Ken-ichi Fukuda,
Kazutaka Ikeda

Affiliations

Yoshinori Aoki: Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan
Daisuke Nishizawa: Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan
Junko Hasegawa: Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan
Shinya Kasai: Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan
Kaori Yoshida: Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan
Yoshihiko Koukita: Department of Dental Anesthesiology, Tokyo Dental College, 2-9-18 Misaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan
Tatsuya Ichinohe: Department of Dental Anesthesiology, Tokyo Dental College, 2-9-18 Misaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan
Makoto Nagashima: Department of Surgery, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura, Chiba 285-8741, Japan
Ryoji Katoh: Department of Surgery, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura, Chiba 285-8741, Japan
Yasuo Satoh: Department of Anesthesiology, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura, Chiba 285-8741, Japan
Megumi Tagami: Department of Anesthesiology, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura, Chiba 285-8741, Japan
Masakazu Hayashida: Department of Anesthesiology, Juntendo University, 3-1-3 Hongou, Bunkyo-ku, Tokyo 113-8431, Japan
Ken-ichi Fukuda: Department of Dental Anesthesiology, Tokyo Dental College, 2-9-18 Misaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan
Kazutaka Ikeda: Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan

DOI: https://doi.org/10.1016/j.jphs.2015.02.005
Journal volume & issue: Vol. 127, no. 3
pp. 391 – 393

Abstract

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An association between postoperative analgesic requirements in subjects who underwent orthognathic surgery and the rs1465040 single-nucleotide polymorphism close to the transient receptor potential subfamily C member 3 (TRPC3) gene was suggested by our previous genome-wide association study. To verify this association, we analyzed the association between the rs1465040 SNP and analgesic requirements, including opioid requirements, after open abdominal surgery. The association between the rs1465040 SNP and postoperative analgesic requirements was confirmed in the open abdominal surgery group (P = 0.036), suggesting that the TRPC3 SNP may contribute to predicting postoperative analgesic requirements.

Published in Journal of Pharmacological Sciences

ISSN: 1347-8613 (Print)
Publisher: Elsevier
Country of publisher: Japan
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://www.journals.elsevier.com/journal-of-pharmacological-sciences

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