Nature Communications (Dec 2016)

Production of individualized V gene databases reveals high levels of immunoglobulin genetic diversity

  • Martin M. Corcoran,
  • Ganesh E. Phad,
  • Néstor Vázquez Bernat,
  • Christiane Stahl-Hennig,
  • Noriyuki Sumida,
  • Mats A.A. Persson,
  • Marcel Martin,
  • Gunilla B. Karlsson Hedestam

DOI
https://doi.org/10.1038/ncomms13642
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

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Current databases of V genes for antibody repertoire have limitations. Here Corcoran et al. develop a computational approach named IgDiscover that can identify germline V gene sequences from expressed antibody repertoires to high specificity and completeness.