Annals of Clinical and Translational Neurology (May 2022)

Correlation of plasma and neuroimaging biomarkers in Alzheimer's disease

  • Adam M. Brickman,
  • Jennifer J. Manly,
  • Lawrence S. Honig,
  • Danurys Sanchez,
  • Dolly Reyes‐Dumeyer,
  • Rafael A. Lantigua,
  • Jean Paul Vonsattel,
  • Andrew F. Teich,
  • Min Suk Kang,
  • Jeffrey L. Dage,
  • Richard Mayeux

DOI
https://doi.org/10.1002/acn3.51529
Journal volume & issue
Vol. 9, no. 5
pp. 756 – 761

Abstract

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Abstract Blood‐based phosphorylated tau (Ptau) 181 and 217 biomarkers are sensitive and specific for Alzheimer's disease. In this racial/ethnically diverse cohort study, participants were classified as biomarker positive (Ptau+) or negative (Ptau‐) based on Ptau 181 and 217 concentrations and as cognitively impaired (Sym) or unimpaired (Asym). The four groups, Ptau‐/Asym, Ptau+/Asym, Ptau‐/Sym, and Ptau+/Sym, differed by age, APOE‐4 allele frequency, total tau, neurofilament light chain, and cortical thickness measured by MRI. Our results add to increasing evidence that plasma Ptau 181 and 217 concentrations are valid Alzheimer's disease biomarkers in diverse populations.