Журнал микробиологии, эпидемиологии и иммунобиологии (Dec 2017)

MOLECULAR AND GENETIC FEATURES OF THE METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) - CAUSATIVE AGENTS OF PURULENT DISEASES AT CANCER PATIENTS

  • O. E. Khokhlova,
  • O. V. Peryanova,
  • O. P. Bobrova,
  • V. K. Sergeeva,
  • A. A. Modestov,
  • O. G. Eremeeva,
  • N. K. Potkina,
  • D. N. Kapshuk,
  • A. V. Alabusheva,
  • T. .. Yamamoto

DOI
https://doi.org/10.36233/0372-9311-2017-6-15-20
Journal volume & issue
Vol. 0, no. 6
pp. 15 – 20

Abstract

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Aim. Study of the molecular and genetic features of the MRSA, causative agents of purulent diseases at cancer patients. Materials and methods. In the work were used - bacteriological method, molecular genetic methods (PCR, M-PCR, sequencing). Results. MRSA share among staphylococcal infections at cancer patients in 2003 - 2007 has made 37,6%, and in 2010 - 2015 has increased up to 51,3%. At a research of molecular and genetic features of the allocated MRS A ] strains, have established, existence of two main clones: ST239/spa3(t037)/SCCmecIIIA and ST8/ . spal(t008)/SCCmecIVc. Representatives of clones differed in resistance level to antibiotics. Conclusion. In cancer patients in Krasnoyarsk, the distribution of two variants of MRSA-ST239Kra$ and ST8Kras, corresponding to the variants common in the Krasnoyarsk region, was revealed. i

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