Nature Communications (Nov 2017)
Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors
- Viktor A. Adalsteinsson,
- Gavin Ha,
- Samuel S. Freeman,
- Atish D. Choudhury,
- Daniel G. Stover,
- Heather A. Parsons,
- Gregory Gydush,
- Sarah C. Reed,
- Denisse Rotem,
- Justin Rhoades,
- Denis Loginov,
- Dimitri Livitz,
- Daniel Rosebrock,
- Ignaty Leshchiner,
- Jaegil Kim,
- Chip Stewart,
- Mara Rosenberg,
- Joshua M. Francis,
- Cheng-Zhong Zhang,
- Ofir Cohen,
- Coyin Oh,
- Huiming Ding,
- Paz Polak,
- Max Lloyd,
- Sairah Mahmud,
- Karla Helvie,
- Margaret S. Merrill,
- Rebecca A. Santiago,
- Edward P. O’Connor,
- Seong H. Jeong,
- Rachel Leeson,
- Rachel M. Barry,
- Joseph F. Kramkowski,
- Zhenwei Zhang,
- Laura Polacek,
- Jens G. Lohr,
- Molly Schleicher,
- Emily Lipscomb,
- Andrea Saltzman,
- Nelly M. Oliver,
- Lori Marini,
- Adrienne G. Waks,
- Lauren C. Harshman,
- Sara M. Tolaney,
- Eliezer M. Van Allen,
- Eric P. Winer,
- Nancy U. Lin,
- Mari Nakabayashi,
- Mary-Ellen Taplin,
- Cory M. Johannessen,
- Levi A. Garraway,
- Todd R. Golub,
- Jesse S. Boehm,
- Nikhil Wagle,
- Gad Getz,
- J. Christopher Love,
- Matthew Meyerson
Affiliations
- Viktor A. Adalsteinsson
- Eli and Edythe L. Broad Institute of MIT and Harvard
- Gavin Ha
- Eli and Edythe L. Broad Institute of MIT and Harvard
- Samuel S. Freeman
- Eli and Edythe L. Broad Institute of MIT and Harvard
- Atish D. Choudhury
- Dana-Farber Cancer Institute
- Daniel G. Stover
- Dana-Farber Cancer Institute
- Heather A. Parsons
- Dana-Farber Cancer Institute
- Gregory Gydush
- Eli and Edythe L. Broad Institute of MIT and Harvard
- Sarah C. Reed
- Eli and Edythe L. Broad Institute of MIT and Harvard
- Denisse Rotem
- Eli and Edythe L. Broad Institute of MIT and Harvard
- Justin Rhoades
- Eli and Edythe L. Broad Institute of MIT and Harvard
- Denis Loginov
- Eli and Edythe L. Broad Institute of MIT and Harvard
- Dimitri Livitz
- Eli and Edythe L. Broad Institute of MIT and Harvard
- Daniel Rosebrock
- Eli and Edythe L. Broad Institute of MIT and Harvard
- Ignaty Leshchiner
- Eli and Edythe L. Broad Institute of MIT and Harvard
- Jaegil Kim
- Eli and Edythe L. Broad Institute of MIT and Harvard
- Chip Stewart
- Eli and Edythe L. Broad Institute of MIT and Harvard
- Mara Rosenberg
- Eli and Edythe L. Broad Institute of MIT and Harvard
- Joshua M. Francis
- Eli and Edythe L. Broad Institute of MIT and Harvard
- Cheng-Zhong Zhang
- Eli and Edythe L. Broad Institute of MIT and Harvard
- Ofir Cohen
- Eli and Edythe L. Broad Institute of MIT and Harvard
- Coyin Oh
- Eli and Edythe L. Broad Institute of MIT and Harvard
- Huiming Ding
- Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Paz Polak
- Eli and Edythe L. Broad Institute of MIT and Harvard
- Max Lloyd
- Dana-Farber Cancer Institute
- Sairah Mahmud
- Dana-Farber Cancer Institute
- Karla Helvie
- Dana-Farber Cancer Institute
- Margaret S. Merrill
- Dana-Farber Cancer Institute
- Rebecca A. Santiago
- Dana-Farber Cancer Institute
- Edward P. O’Connor
- Dana-Farber Cancer Institute
- Seong H. Jeong
- Dana-Farber Cancer Institute
- Rachel Leeson
- Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Rachel M. Barry
- Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Joseph F. Kramkowski
- Dana-Farber Cancer Institute
- Zhenwei Zhang
- Dana-Farber Cancer Institute
- Laura Polacek
- Dana-Farber Cancer Institute
- Jens G. Lohr
- Eli and Edythe L. Broad Institute of MIT and Harvard
- Molly Schleicher
- Eli and Edythe L. Broad Institute of MIT and Harvard
- Emily Lipscomb
- Eli and Edythe L. Broad Institute of MIT and Harvard
- Andrea Saltzman
- Eli and Edythe L. Broad Institute of MIT and Harvard
- Nelly M. Oliver
- Dana-Farber Cancer Institute
- Lori Marini
- Dana-Farber Cancer Institute
- Adrienne G. Waks
- Dana-Farber Cancer Institute
- Lauren C. Harshman
- Dana-Farber Cancer Institute
- Sara M. Tolaney
- Dana-Farber Cancer Institute
- Eliezer M. Van Allen
- Eli and Edythe L. Broad Institute of MIT and Harvard
- Eric P. Winer
- Dana-Farber Cancer Institute
- Nancy U. Lin
- Dana-Farber Cancer Institute
- Mari Nakabayashi
- Dana-Farber Cancer Institute
- Mary-Ellen Taplin
- Dana-Farber Cancer Institute
- Cory M. Johannessen
- Eli and Edythe L. Broad Institute of MIT and Harvard
- Levi A. Garraway
- Eli and Edythe L. Broad Institute of MIT and Harvard
- Todd R. Golub
- Eli and Edythe L. Broad Institute of MIT and Harvard
- Jesse S. Boehm
- Eli and Edythe L. Broad Institute of MIT and Harvard
- Nikhil Wagle
- Eli and Edythe L. Broad Institute of MIT and Harvard
- Gad Getz
- Eli and Edythe L. Broad Institute of MIT and Harvard
- J. Christopher Love
- Eli and Edythe L. Broad Institute of MIT and Harvard
- Matthew Meyerson
- Eli and Edythe L. Broad Institute of MIT and Harvard
- DOI
- https://doi.org/10.1038/s41467-017-00965-y
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Identifying the mutational landscape of tumours from cell-free DNA in the blood could help diagnostics in cancer. Here, the authors present ichorCNA, software that quantifies tumour content in cell free DNA, and they demonstrate that cell-free DNA whole-exome sequencing is concordant with metastatic tumour whole-exome sequencing.
