Cyclization of 2′-hydroxychalcones to flavones using ammonium iodide as an iodine source: An eco-friendly approach

Abstract

Ammonium iodide in open air decomposes to ammonia and iodine. The in situ generated iodine has been used for cyclization of 2′-hydroxychalcones to corresponding flavones under solvent free conditions with good to excellent yields. This method would serve as an attractive alternative to the existing methods for synthesis of flavones and use of toxic molecular iodine is avoided.

Keywords

• flavones
• 2’-hydroxychalcone
• ammonium iodide
• solvent free
• in situ iodine