A classification system for tableting behaviors of binary powder mixtures

Asian Journal of Pharmaceutical Sciences. 2016;11(4):486-491 DOI 10.1016/j.ajps.2015.11.122


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Journal Title: Asian Journal of Pharmaceutical Sciences

ISSN: 1818-0876 (Print)

Publisher: Elsevier

Society/Institution: Shenyang Pharmaceutical University

LCC Subject Category: Medicine: Therapeutics. Pharmacology

Country of publisher: Hong Kong

Language of fulltext: English

Full-text formats available: PDF, HTML



Changquan Calvin Sun


Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 17 weeks


Abstract | Full Text

The ability to predict tableting properties of a powder mixture from individual components is of both fundamental and practical importance to the efficient formulation development of tablet products. A common tableting classification system (TCS) of binary powder mixtures facilitates the systematic development of new knowledge in this direction. Based on the dependence of tablet tensile strength on weight fraction in a binary mixture, three main types of tableting behavior are identified. Each type is further divided to arrive at a total of 15 sub-classes. The proposed classification system lays a framework for a better understanding of powder interactions during compaction. Potential applications and limitations of this classification system are discussed.