Communications Biology (Feb 2023)

RhoGDIα regulates spermatogenesis through Rac1/cofilin/F-actin signaling

  • Haixia Zhu,
  • Zongzhuang Wen,
  • Aizhen Zhang,
  • Dongyue Liu,
  • Hongxiang Wang,
  • Yin Cheng,
  • Xing Yang,
  • Yu Xiao,
  • Jianyuan Li,
  • Daqing Sun,
  • Bin Wu,
  • Jiangang Gao

DOI
https://doi.org/10.1038/s42003-023-04579-7
Journal volume & issue
Vol. 6, no. 1
pp. 1 – 14

Abstract

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RhoGDIα knockout mice show low male fertility and compromised spermatogenesis, with an underlying defect in F-actin cytoskeleton depolymerisation, which can be alleviated by inhibiting Rac1.