Nature Communications (May 2021)

Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer

  • Martin Obr,
  • Clifton L. Ricana,
  • Nadia Nikulin,
  • Jon-Philip R. Feathers,
  • Marco Klanschnig,
  • Andreas Thader,
  • Marc C. Johnson,
  • Volker M. Vogt,
  • Florian K. M. Schur,
  • Robert A. Dick

DOI
https://doi.org/10.1038/s41467-021-23506-0
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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Inositol hexakisphosphate (IP6) is a known assembly cofactor for HIV-1. Here, the authors show the role of IP6 in the assembly of the Rous sarcoma virus (RSV). Reported cryo-ET structures of mature capsid-like particles (CLPs) suggest that IP6 modulates the formation of capsid polyhedrons of variable shape.