Nature Communications (Jan 2023)
Mechanism of regulation of the Helicobacter pylori Cagβ ATPase by CagZ
- Xiuling Wu,
- Yanhe Zhao,
- Hong Zhang,
- Wendi Yang,
- Jinbo Yang,
- Lifang Sun,
- Meiqin Jiang,
- Qin Wang,
- Qianchao Wang,
- Xianren Ye,
- Xuewu Zhang,
- Yunkun Wu
Affiliations
- Xiuling Wu
- Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, Fujian Key Laboratory of Developmental and Neural Biology, Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, College of Life Sciences, Fujian Normal University
- Yanhe Zhao
- Department of Cell Biology, University of Texas Southwestern Medical Center
- Hong Zhang
- Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, Fujian Key Laboratory of Developmental and Neural Biology, Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, College of Life Sciences, Fujian Normal University
- Wendi Yang
- Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, Fujian Key Laboratory of Developmental and Neural Biology, Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, College of Life Sciences, Fujian Normal University
- Jinbo Yang
- Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, Fujian Key Laboratory of Developmental and Neural Biology, Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, College of Life Sciences, Fujian Normal University
- Lifang Sun
- Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, Fujian Key Laboratory of Developmental and Neural Biology, Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, College of Life Sciences, Fujian Normal University
- Meiqin Jiang
- Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, Fujian Key Laboratory of Developmental and Neural Biology, Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, College of Life Sciences, Fujian Normal University
- Qin Wang
- Department of Biochemistry and Molecular Biology, Binzhou Medical University
- Qianchao Wang
- Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, Fujian Key Laboratory of Developmental and Neural Biology, Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, College of Life Sciences, Fujian Normal University
- Xianren Ye
- Fujian Cancer Hospital & Fujian Medical University Cancer Hospital
- Xuewu Zhang
- Department of Pharmacology, University of Texas Southwestern Medical Center
- Yunkun Wu
- Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, Fujian Key Laboratory of Developmental and Neural Biology, Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, College of Life Sciences, Fujian Normal University
- DOI
- https://doi.org/10.1038/s41467-023-36218-4
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 13
Abstract
Cagβ is an ATPase in the H. pylori CagType4 secretion system essential for delivering the CagA effector to host cells. Here, authors present crystal structures of hexameric apo-Cagβ and Cagβ trapped in the monomeric state by its regulator CagZ, uncovering the regulatory mechanisms of Cagβ.
