Nature Communications (Oct 2017)

Deletion of 3p13-14 locus spanning FOXP1 to SHQ1 cooperates with PTEN loss in prostate oncogenesis

  • Haley Hieronymus,
  • Phillip J. Iaquinta,
  • John Wongvipat,
  • Anuradha Gopalan,
  • Rajmohan Murali,
  • Ninghui Mao,
  • Brett S. Carver,
  • Charles L. Sawyers

DOI
https://doi.org/10.1038/s41467-017-01198-9
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 10

Abstract

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Although the locus at 3p13-14 is commonly deleted in prostate cancer, the identity of the potential driver genes is still unclear. Here, the authors, using a PTEN loss-driven prostate cancer mouse model, show that a multigenic FOXP1-SHQ1 deletion is a driver event with prognostic value.