Microwave-Assisted Synthesis of Aryl Phosphonates and Tertiary Phosphine Oxides by the Hirao Reaction

Abstract

Our group described a green, “P-ligand-free”, Pd(OAc)2- or NiCl2-catalyzed synthesis under MW conditions. The reactivity of a few aryl derivatives in the Pd(OAc)2-catalyzed, “P-ligand-free” P–C coupling reactions under MW condition was also studied. An induction period was observed. Finally, the less known copper(I)-promoted reactions were investigated experimentally. The mechanism was explored by quantum chemical calculations.

Keywords

• P–C coupling
• Hirao reaction
• microwave
• palladium catalyst
• nickel catalyst
• copper(I) catalyst