Usefulness of optical coherence tomography angiography in choroidal neovascularization secondary to neovascular age-related macular degeneration

Abstract

Background: Optical coherence tomography angiography (OCTA) could be a valid tool to detect choroidal neovascularization (CNV) in neovascular age-related macular degeneration (nAMD), allowing the analysis of the type, the morphology, and the extension of CNV in most of the cases. Aim: The aim of the study was to highlight the role of OCTA in the nAMD. Setting and Design: This retrospective, cross-sectional study is done at tertiary eye care center. Materials and Methods: This study enrolled 24 patients (48 eyes). All patients underwent swept-source optical coherence tomography, swept-source OCTA, and fundus fluorescein angiography (FFA). OCTA was used to evaluate neovascular networks in terms of their type, location, and extent of visualization. Sensitivity and specificity of the method were assessed based on FFA diagnosis as the gold standard. Results: In our study, the sensitivity and specificity of OCTA in detecting CNV secondary to neovascular AMD seem to be high which were 85.1% and 80%, respectively. Conclusion: OCTA may be clinically useful to evaluate the CNV activity and response to treatment as well as to differentiate the various types of CNV in neovascular nAMD.

Keywords

• age-related macular degeneration
• choroidal neovascularization
• optical coherence tomography angiography