Effects of Stimulus Luminance, Stimulus Color and Intra-Stimulus Color Contrast on Visual Field Mapping in Neurologically Impaired Adults Using Flicker Pupil Perimetry

Abstract

Brendan L Portengen,1,2 Giorgio L Porro,1,* Douwe Bergsma,3 Evert J Veldman,4 Saskia M Imhof,1 Marnix Naber2,* 1Department of Ophthalmology, University Medical Center Utrecht, Utrecht, the Netherlands; 2Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, the Netherlands; 3HemianopsieStichting, Amersfoort, the Netherlands; 4Bartiméus Foundation, Zeist, the Netherlands*These authors contributed equally to this workCorrespondence: Brendan L Portengen, Department of Ophthalmology, University Medical Center Utrecht, PO Box 85500, Room E 03.136, Utrecht, 3508 GA, the Netherlands, Email [email protected]: We improve pupillary responses and diagnostic performance of flicker pupil perimetry through alterations in global and local color contrast and luminance contrast in adult patients suffering from visual field defects due to cerebral visual impairment (CVI).Methods: Two experiments were conducted on patients with CVI (Experiment 1: 19 subjects, age M and SD 57.9 ± 14.0; Experiment 2: 16 subjects, age M and SD 57.3 ± 14.7) suffering from absolute homonymous visual field (VF) defects. We altered global color contrast (stimuli consisted of white, yellow, cyan and yellow-equiluminant-to-cyan colored wedges) in Experiment 1, and we manipulated luminance and local color contrast with bright and dark yellow and multicolor wedges in a 2-by-2 design in Experiment 2. Stimuli consecutively flickered across 44 stimulus locations within the inner 60 degrees of the VF and were offset to a contrasting (opponency colored) dark background. Pupil perimetry results were compared to standard automated perimetry (SAP) to assess diagnostic accuracy.Results: A bright stimulus with global color contrast using yellow (p= 0.009) or white (p= 0.006) evoked strongest pupillary responses as opposed to stimuli containing local color contrast and lower brightness. Diagnostic accuracy, however, was similar across global color contrast conditions in Experiment 1 (p= 0.27) and decreased when local color contrast and less luminance contrast was introduced in Experiment 2 (p= 0.02). The bright yellow condition resulted in highest performance (AUC M = 0.85 ± 0.10, Mdn = 0.85).Conclusion: Pupillary responses and pupil perimetry’s diagnostic accuracy both benefit from high luminance contrast and global but not local color contrast.Keywords: perimetry, pupillometry, visual field, scotoma, color contrast, luminance contrast

Keywords

• perimetry
• pupillometry
• visual field
• scotoma
• color contrast
• luminance contrast