The Complex Network between MYC Oncogene and microRNAs in Gastric Cancer: An Overview

Ana  Carolina Anauate; Mariana  Ferreira Leal; Danielle  Queiroz Calcagno; Carolina  Oliveira Gigek; Bruno  Takao Real Karia; Fernanda Wisnieski; Leonardo  Caires dos Santos; Elizabeth  Suchi Chen; Rommel  Rodríguez Burbano; Marília  Arruda Cardoso Smith

doi:10.3390/ijms21051782

International Journal of Molecular Sciences (Mar 2020)

The Complex Network between MYC Oncogene and microRNAs in Gastric Cancer: An Overview

Ana Carolina Anauate,
Mariana Ferreira Leal,
Danielle Queiroz Calcagno,
Carolina Oliveira Gigek,
Bruno Takao Real Karia,
Fernanda Wisnieski,
Leonardo Caires dos Santos,
Elizabeth Suchi Chen,
Rommel Rodríguez Burbano,
Marília Arruda Cardoso Smith

Affiliations

Ana Carolina Anauate: Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de São Paulo, São Paulo SP 04023-062, Brazil
Mariana Ferreira Leal: Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de São Paulo, São Paulo SP 04023-062, Brazil
Danielle Queiroz Calcagno: Núcleo de Pesquisas em Oncologia, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Belém PA 66075-110, Brazil
Carolina Oliveira Gigek: Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de São Paulo, São Paulo SP 04023-062, Brazil
Bruno Takao Real Karia: Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de São Paulo, São Paulo SP 04023-062, Brazil
Fernanda Wisnieski: Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de São Paulo, São Paulo SP 04023-062, Brazil
Leonardo Caires dos Santos: Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de São Paulo, São Paulo SP 04023-062, Brazil
Elizabeth Suchi Chen: Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de São Paulo, São Paulo SP 04023-062, Brazil
Rommel Rodríguez Burbano: Núcleo de Pesquisas em Oncologia, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Belém PA 66075-110, Brazil
Marília Arruda Cardoso Smith: Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de São Paulo, São Paulo SP 04023-062, Brazil

DOI: https://doi.org/10.3390/ijms21051782
Journal volume & issue: Vol. 21, no. 5
p. 1782

Abstract

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Despite the advancements in cancer treatments, gastric cancer is still one of the leading causes of death worldwide. In this context, it is of great interest to discover new and more effective ways of treating this disease. Accumulated evidences have demonstrated the amplification of 8q24.21 region in gastric tumors. Furthermore, this is the region where the widely known MYC oncogene and different microRNAs are located. MYC deregulation is key in tumorigenesis in various types of tissues, once it is associated with cell proliferation, survival, and drug resistance. microRNAs are a class of noncoding RNAs that negatively regulate the protein translation, and which deregulation is related with gastric cancer development. However, little is understood about the interactions between microRNAs and MYC. Here, we overview the MYC role and its relationship with the microRNAs network in gastric cancer aiming to identify potential targets useful to be used in clinic, not only as biomarkers, but also as molecules for development of promising therapies.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

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