Communications Biology (Sep 2022)

Curcumin-based-fluorescent probes targeting ALDH1A3 as a promising tool for glioblastoma precision surgery and early diagnosis

  • Edoardo L. M. Gelardi,
  • Diego Caprioglio,
  • Giorgia Colombo,
  • Erika Del Grosso,
  • Daniele Mazzoletti,
  • Daiana Mattoteia,
  • Stefano Salamone,
  • Davide M. Ferraris,
  • Eleonora Aronica,
  • Giulia Nato,
  • Annalisa Buffo,
  • Menico Rizzi,
  • Lorenzo Magrassi,
  • Alberto Minassi,
  • Silvia Garavaglia

DOI
https://doi.org/10.1038/s42003-022-03834-7
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 14

Abstract

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Curcumin-based fluorescent probes are presented that are able to selectively bind to aldehyde dehydrogenase 1A3 (ALDH1A3), an enzyme overexpressed in glioma stem cells and specifically identify glioblastoma cells in vitro and in vivo.